PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Abstract Background d-3-phosphoglycerate dehydrogenase (PHGDH), which Winter Sports - Hard Goods encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target.However, whether PHGDH is critical for the proliferation or homeostasis of tissues following the postnatal period is unknown.Method